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NEWS & VIEWS
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Evolutionary biology: Genomic hourglass pp768 - 769
Comparative genomics studies reveal molecular signatures of the  controversial 'phylotypic' stage — a time when embryos of members of  an animal phylum all look more alike than at other embryonic stages.  See Letters p.811 & p.815
Benjamin Prud'homme and Nicolas Gompel
doi:10.1038/468768a
Article: http://www.nature.com/nature/journal/v468/n7325/full/468768a.html

Quantum physics: Hot entanglement pp769 - 770
Quantum entanglement has been observed at low temperatures in both  microscopic and macroscopic systems. It now seems that the effect can  also occur at high temperatures if the systems are not in thermal  equilibrium.
Vlatko Vedral
doi:10.1038/468769a
Article: http://www.nature.com/nature/journal/v468/n7325/full/468769a.html

Cancer: Tumour stem cells switch sides pp770 - 771
Tumour stem cells are proposed to be the source of tumour cells. It  now emerges that they also give rise to the endothelial cells that  line the tumour vasculature, mediating tumour growth and metastasis.  See Letters p.824 & p.829
Victoria L. Bautch
doi:10.1038/468770a
Article: http://www.nature.com/nature/journal/v468/n7325/full/468770a.html

50 & 100 years ago p772
doi:10.1038/468772a
Article: http://www.nature.com/nature/journal/v468/n7325/full/468772a.html

Cosmology: Hydrogen was not ionized abruptly pp772 - 773
When and how the first stars and galaxies ionized the primordial  hydrogen atoms that filled the early Universe is not known.  Observations with a single radio antenna are opening a new window on  the process. See Letter p.796
Jonathan Pritchard and Abraham Loeb
doi:10.1038/468772b
Article: http://www.nature.com/nature/journal/v468/n7325/full/468772b.html

Virology: One protein, many functions pp773 - 775
The Lassa virus nucleoprotein coats the viral genome to make a  template for RNA synthesis. A study shows that it also binds the 'cap'  structure of cellular messenger RNAs and directs immune evasion using  a novel mechanism. See Article p.779
Félix A. Rey
doi:10.1038/468773a
Article: http://www.nature.com/nature/journal/v468/n7325/full/468773a.html

Solar system: Pluto is again a harbinger pp775 - 776
New astronomical and laboratory data show that the abundances of the  two dominant ices, nitrogen and methane, on the surfaces of the Solar  System's two largest dwarf planets are surprisingly similar — raising  fresh questions.
S. Alan Stern
doi:10.1038/468775a
Article: http://www.nature.com/nature/journal/v468/n7325/full/468775a.html

Glaciology: Greenland's glacial basics pp776 - 777
Sliding of the Greenland ice sheet is affected by the production of  surface meltwater. A new theory shows that whether the result is a  long-term speed-up or slow-down of ice motion depends on the  variability in melt input. See Letter p.803
Martin P. Lüthi
doi:10.1038/468776a
Article: http://www.nature.com/nature/journal/v468/n7325/full/468776a.html

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ARTICLES
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Cap binding and immune evasion revealed by Lassa nucleoprotein  structure pp779 - 783
The first crystal structure for an arenavirus nucleoprotein is solved,  revealing some new functions. The C-terminal domain has 3′ to 5′  exonuclease activity, and it is confirmed that Lassa virus  nucleoprotein is capable of cleaving short RNAs and suppressing virus- induced interferon induction. The N-terminal domain contains a unique  cap-binding feature, which has implications for understanding the  distinctive cap-snatching mechanism of arenaviruses.

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