Interdependence of behavioural variability and response to small  stimuli in bacteria pp819 - 823
In his study of Brownian motion, Einstein realized that the same  random molecular movements characterizing a substance at rest should  affect, for example, the drag it opposes to a particle pushed through  it. This was later generalized as the fluctuation–response theorem  (FRT), but whether and how it may apply to biological systems, which  operate far from equilibrium, has remained an open question. Based on  the unmatched fine-scale measurements possible in the study of  bacterial chemotaxis, it is now revealed that the FRT does apply in  this case, and ways to dissect which features in the biochemical  network couple its internal states with its responses to external  stimuli are suggested.
Heungwon Park et al.
doi:10.1038/nature09551
Abstract: http://www.nature.com/nature/journal/v468/n7325/abs/nature09551.html
Article: http://www.nature.com/nature/journal/v468/n7325/full/nature09551.html

Tumour vascularization via endothelial differentiation of glioblastoma  stem-like cells pp824 - 828
This is one of two papers showing that glioblastoma cells can  differentiate into functional endothelial cells as part of the tumour  vasculature. These endothelial cells are characterized by the same  genetic alterations as the glioblastoma cells. The tumour-derived  endothelial cells originate in putative glioblastoma-initiating cells  and are functionally important for tumorigenesis.
Lucia Ricci-Vitiani et al.
doi:10.1038/nature09557
Abstract: http://www.nature.com/nature/journal/v468/n7325/abs/nature09557.html
Article: http://www.nature.com/nature/journal/v468/n7325/full/nature09557.html

Glioblastoma stem-like cells give rise to tumour endothelium pp829 - 833
This is one of two papers showing that glioblastoma cells can  differentiate into functional endothelial cells as part of the tumour  vasculature. These endothelial cells are characterized by the same  genetic alterations as the glioblastoma cells. The tumour-derived  endothelial cells originate in putative glioblastoma-initiating cells  and are functionally important for tumorigenesis.
Rong Wang et al.
doi:10.1038/nature09624
Abstract: http://www.nature.com/nature/journal/v468/n7325/abs/nature09624.html
Article: http://www.nature.com/nature/journal/v468/n7325/full/nature09624.html

Calcium-dependent phospholipid scrambling by TMEM16F pp834 - 838
Lipid asymmetry can be disrupted during biological processes such as  apoptosis, during which phosphatidylserine in the inner leaflet of the  membrane is exposed on the outer membrane. It has been proposed that  activation of a phospholipid scramblase catalyses bidirectional  transbilayer movement of phospholipids, but the protein corresponding  to this activity has not been identified. Here, the protein TMEM16F is  identified, and is an essential component for the Ca2+-dependent  exposure of phosphatidylserine on the plasma membrane. A patient with  Scott syndrome, which results from a defect in phospholipid scrambling  activity, was found to carry a mutation in the gene encoding TMEM16F.
Jun Suzuki, Masato Umeda, Peter J. Sims and Shigekazu Nagata
doi:10.1038/nature09583
Abstract: http://www.nature.com/nature/journal/v468/n7325/abs/nature09583.html
Article: http://www.nature.com/nature/journal/v468/n7325/full/nature09583.html

Impaired hydroxylation of 5-methylcytosine in myeloid cancers with  mutant TET2 pp839 - 843

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