《Nature》目录要览：2010-12-09出版
时间：2010-12-09 阅读： 我要评论:
The TET family of enzymes convert 5-methylcytosine (5mC) to 5- hydroxymethylcytosine (5hmC) in DNA. Mutations in the gene encoding TET2 are frequently observed in myeloid malignancies. Here it is shown that these disease-associated mutations compromise TET2 catalytic activity; bone marrow samples from patients with TET2 mutations have low levels of 5hmC in genomic DNA, and TET2 is required for normal haematopoietic differentiation. Measurement of genomic 5hmC levels may prove valuable as a diagnostic tool in myeloid cancers.
Myunggon Ko et al.
doi:10.1038/nature09586
Abstract: http://www.nature.com/nature/journal/v468/n7325/abs/nature09586.html
Article: http://www.nature.com/nature/journal/v468/n7325/full/nature09586.html
Design, function and structure of a monomeric ClC transporter pp844 - 847
Channels and transporters in the ClC family are homodimeric; however, the aqueous pores for anion diffusion in the channels and the ion- coupling chambers that coordinate Cl− and H+ antiport in the transporters are contained wholly within each subunit of the homodimer. Here mutations in a Cl−/H+ exchanger were made that destabilized the dimer interface; the resulting mutant channel is monomeric, yet it is functionally nearly identical to the wild-type channel. This means that cross-subunit interaction is not required for Cl−/H+ exchange in ClC transporters, which raises the question: why is the wild-type transporter a homodimer?
Janice L. Robertson, Ludmila Kolmakova-Partensky and Christopher Miller
doi:10.1038/nature09556
Abstract: http://www.nature.com/nature/journal/v468/n7325/abs/nature09556.html
Article: http://www.nature.com/nature/journal/v468/n7325/full/nature09556.html
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TECHNOLOGY FEATURES
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Protein–protein interactions: Interactome under construction pp851 - 854
Developing techniques are helping researchers to build the protein interaction networks that underlie all cell functions.
Laura Bonetta
doi:10.1038/468851a
http://www.nature.com/nature/journal/v468/n7325/full/468851a.html
Protein–protein interactions: Tools for the search p852
doi:10.1038/468852a
http://www.nature.com/nature/journal/v468/n7325/full/468852a.html
Protein–protein interactions: Real-time analysis p854
doi:10.1038/468854a
http://www.nature.com/nature/journal/v468/n7325/full/468854a.html
Protein–protein interactions: Table of suppliers pp855 - 856
doi:10.1038/468855a
http://www.nature.com/nature/journal/v468/n7325/full/468855a.html
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FUTURES
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The cleverest man in the world p862
Problem solved.
Tony Ballantyne
doi:10.1038/468862a
http://www.nature.com/nature/journal/v468/n7325/full/468862a.html
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