精神分裂症的深层病因（Schizophrenia connections）
Impaired hippocampal–prefrontal synchrony in a genetic mouse model of schizophrenia
“22q11.2微缺失（微删除）”是精神分裂症最可靠的已知遗传风险因素之一。相应染色体区域有一处中断的小鼠会有工作记忆问题，这是精神分裂症 的一个特征。Sigurdsson等人发现，这些小鼠前额皮质和海马神经元之间的同步激发也有中断，这种同步激发是一个已被与学习和记忆联系在一起的现象，而且它在精神分裂症患者中也受到破坏。这些发现表明，脑中这些区域之间沟通的破坏可能是精神分裂症发病的深层原因，而试图修复这种破坏的工作可能会导致新疗法的问世。（Letter p. 763）

----------------------
NEWS AND VIEWS
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Cell biology forum: Genome-wide view of mitosis    pp684-685
An exceptionally large-scale project aimed at assigning function to all
protein-coding genes in the human genome is reported on page 721 by Neumann
et al.. Here are two complementary views on the experimental design and
analysis, and on how useful the findings will be to cell biologists.
Jason R. Swedlow, Cecilia Cotta-Ramusino and Stephen J. Elledge
doi:10.1038/464684a
http://www.nature.com/nature/journal/v464/n7289/full/464684a.html

Quantum mechanics: The surf is up    pp685-686
Researchers have long wanted to be able to control macroscopic mechanical
objects in their smallest possible state of motion. Success in achieving
that goal heralds a new generation of quantum experiments.
Markus Aspelmeyer
doi:10.1038/464685a
http://www.nature.com/nature/journal/v464/n7289/full/464685a.html

Stem cells: Skin regeneration and repair    pp686-687
Different types of stem cell maintain the skin's epidermis and contribute
to its healing after damage. The identity of a stem-cell type that gives
rise to different epidermal-cell lineages has just been revealed.
Cedric Blanpain
doi:10.1038/464686a
http://www.nature.com/nature/journal/v464/n7289/full/464686a.html

Early Earth: Faint young Sun redux    pp687-689
Given that the Sun was dimmer in its youth, our planet should have been
frozen over for much of its early history. That it evidently wasn't is a
puzzle that continues to engage the attention of Earth scientists.
James F. Kasting
doi:10.1038/464687a
http://www.nature.com/nature/journal/v464/n7289/full/464687a.html

Drug discovery: Fat-free proteins kill parasites    pp689-690
The addition of a fatty acid to certain proteins is vital for the survival
of protozoa that cause sleeping sickness and of their mammalian hosts.
Compounds that target this process in the protozoa are now reported.
George A. M. Cross
doi:10.1038/464689a
http://www.nature.com/nature/journal/v464/n7289/full/464689a.html

Physiology: There is no single p    pp691-693
Why metabolic rates do not vary in direct proportion to body mass has
long been the subject of debate. Progress has been made with the realization

that no universal scaling exponent can be applied to them.
Craig R. White
doi:10.1038/464691a

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