英国《Nature》目录要览：2010-04-01出版
时间：2010-04-02 阅读： 我要评论:
http://www.nature.com/nature/journal/v464/n7289/abs/nature08516.html
Article:
http://www.nature.com/nature/journal/v464/n7289/full/nature08516.html
Genome-wide association study of CNVs in 16,000 cases of eight common
diseases
and 3,000 shared controls pp713-720
Copy number variants (CNVs) account for a major proportion of human genetic
diversity and may contribute to genetic susceptibility to disease. Here, a
large, genome-wide study of association between common CNVs and eight common
human diseases is presented. The study provides a wealth of technical
insights
that will inform future study design and analysis. The results also indicate
that common CNVs that can be 'typed' on existing platforms are unlikely to
contribute much to the genetic basis of common diseases.
Nick Craddock et al.
doi:10.1038/nature08979
Abstract:
http://www.nature.com/nature/journal/v464/n7289/abs/nature08979.html
Article:
http://www.nature.com/nature/journal/v464/n7289/full/nature08979.html
Phenotypic profiling of the human genome by time-lapse microscopy reveals
cell
division genes pp721-727
High-throughput microscopy combined with gene silencing by RNA interference
is
a powerful method for studying gene function. Here, a genome-wide method is
presented for phenotypic screening of each of the [sim]21,000 human
protein-coding
genes, using two-day imaging of dividing cells with fluorescently labelled
chromosomes. The method enabled the identification of hundreds of genes
involved
in biological functions such as cell division, migration and survival.
Beate Neumann et al.
doi:10.1038/nature08869
Abstract:
http://www.nature.com/nature/journal/v464/n7289/abs/nature08869.html
Article:
http://www.nature.com/nature/journal/v464/n7289/full/nature08869.html
N-myristoyltransferase inhibitors as new leads to treat sleeping
sickness
pp728-732
African sleeping sickness, caused by Trypanosoma brucei species, is
responsible
for some 30,000 human deaths each year. Available treatments are limited by
poor
efficacy and safety profiles. However, a new molecular target for potential
treatments has now been identified. The protein target is T.
bruceiN-myristoyltransferase.
In further experiments, lead compounds have been discovered that inhibit
this protein, kill trypanosomes in vitro and in vivo, and can cure
trypanosomiasis in mice.
Julie A. Frearson et al.
doi:10.1038/nature08893
Abstract:
http://www.nature.com/nature/journal/v464/n7289/abs/nature08893.html
Article:
Article:
http://www.nature.com/nature/journal/v464/n7289/full/nature08516.html
Genome-wide association study of CNVs in 16,000 cases of eight common
diseases
and 3,000 shared controls pp713-720
Copy number variants (CNVs) account for a major proportion of human genetic
diversity and may contribute to genetic susceptibility to disease. Here, a
large, genome-wide study of association between common CNVs and eight common
human diseases is presented. The study provides a wealth of technical
insights
that will inform future study design and analysis. The results also indicate
that common CNVs that can be 'typed' on existing platforms are unlikely to
contribute much to the genetic basis of common diseases.
Nick Craddock et al.
doi:10.1038/nature08979
Abstract:
http://www.nature.com/nature/journal/v464/n7289/abs/nature08979.html
Article:
http://www.nature.com/nature/journal/v464/n7289/full/nature08979.html
Phenotypic profiling of the human genome by time-lapse microscopy reveals
cell
division genes pp721-727
High-throughput microscopy combined with gene silencing by RNA interference
is
a powerful method for studying gene function. Here, a genome-wide method is
presented for phenotypic screening of each of the [sim]21,000 human
protein-coding
genes, using two-day imaging of dividing cells with fluorescently labelled
chromosomes. The method enabled the identification of hundreds of genes
involved
in biological functions such as cell division, migration and survival.
Beate Neumann et al.
doi:10.1038/nature08869
Abstract:
http://www.nature.com/nature/journal/v464/n7289/abs/nature08869.html
Article:
http://www.nature.com/nature/journal/v464/n7289/full/nature08869.html
N-myristoyltransferase inhibitors as new leads to treat sleeping
sickness
pp728-732
African sleeping sickness, caused by Trypanosoma brucei species, is
responsible
for some 30,000 human deaths each year. Available treatments are limited by
poor
efficacy and safety profiles. However, a new molecular target for potential
treatments has now been identified. The protein target is T.
bruceiN-myristoyltransferase.
In further experiments, lead compounds have been discovered that inhibit
this protein, kill trypanosomes in vitro and in vivo, and can cure
trypanosomiasis in mice.
Julie A. Frearson et al.
doi:10.1038/nature08893
Abstract:
http://www.nature.com/nature/journal/v464/n7289/abs/nature08893.html
Article:
| 《Nature》目录要览 — 2011-04-28出版 |
| 《Nature》目录要览：2011-01-20出版 |
| 《Nature》目录要览：2010-12-23出版 |
| 《Nature》目录要览：2010-12-16出版 |
| 《Nature》目录要览：2010-12-09出版 |
| 《Nature》目录要览：2010-12-02出版 |
特别声明：本文转载仅仅是出于传播信息的需要，版权归原作者所有，并不意味着代表本网站观点或证实其内容的真实性； 如其他媒体、网站或个人从本网站转载使用，须保留本网站注明的“来源”，并自负版权等法律责任； 作者如果不希望被转载或者联系转载稿费等事宜，请与我们接洽：service#environmentor.cn（请将#改为@）。
来源：Nature 作者：Environmentor （环境人 Environmentor.Cn）
