英国《Nature》：2010年3月25日出版
时间：2010-03-26 阅读： 我要评论:
Article:
http://www.nature.com/nature/journal/v464/n7288/full/nature08899.html
Heteroplasmic mitochondrial DNA mutations in normal and tumour
cells pp610-614
Each human cell contains hundreds of copies of mitochondrial DNA (mtDNA),
making it difficult to characterize mtDNA completely. Here, massively
parallel
sequencing-by-synthesis of mtDNA reveals widespread heterogeneity
(heteroplasmy)
in the mtDNA of normal human cells, and homoplasmic and heteroplasmic
mutations
in cancer cells. The findings provide new insight into the nature and
variability
of mtDNA sequences, with implications for forensic analysis and the
development
of biomarkers for cancer.
Yiping He et al.
doi:10.1038/nature08802
Abstract:
http://www.nature.com/nature/journal/v464/n7288/abs/nature08802.html
Article:
http://www.nature.com/nature/journal/v464/n7288/full/nature08802.html
Haploid plants produced by centromere-mediated genome
elimination pp615-618
Making haploid plants - which inherit chromosomes from only one parent - is
useful for genetic research and also, crucially, for plant breeding. A new
method for generating haploid Arabidopsis plants is now described, involving
the manipulation of a single centromeric protein, CENH3. When cenh3 null
plants are crossed with wild-type plants, the mutant chromosomes are
eliminated, producing haploid progeny.
Maruthachalam Ravi and Simon W. L. Chan
doi:10.1038/nature08842
Abstract:
http://www.nature.com/nature/journal/v464/n7288/abs/nature08842.html
Article:
http://www.nature.com/nature/journal/v464/n7288/full/nature08842.html
Transcriptional control of preadipocyte determination by Zfp423 pp619-623
An understanding of how fat cells (adipocytes) develop will contribute to
our
understanding of obesity. The differentiation of committed preadipocytes
into adipocytes is known to be controlled by PPAR[gamma] and several other
transcription factors. But what turns a cell into a preadipocyte? Here, the
zinc-finger protein Zfp423 is identified as a transcriptional regulator of
preadipocyte determination.
Rana K. Gupta et al.
doi:10.1038/nature08816
Abstract:
http://www.nature.com/nature/journal/v464/n7288/abs/nature08816.html
Article:
http://www.nature.com/nature/journal/v464/n7288/full/nature08816.html
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