英国《Nature》：2010年3月25日出版
时间：2010-03-26 阅读： 我要评论:
Transcription-independent ARF regulation in oncogenic stress-mediated p53
responses pp624-627
In response to oncogenic stress, the tumour suppressor ARF activates the p53
protein. ARF protein is highly stable in most human cell lines, so it has
been thought that ARF activation occurs mainly at the level of
transcription.
Here, however, ARF is shown to be unstable in normal human cells but stable
in
cancer cells, through a transcription-independent mechanism. A ubiquitin
ligase
for ARF is identified and shown to promote ARF degradation in normal cells.
This
activity is prevented in cancer cells, stabilizing ARF.
Delin Chen et al.
doi:10.1038/nature08820
Abstract:
http://www.nature.com/nature/journal/v464/n7288/abs/nature08820.html
Article:
http://www.nature.com/nature/journal/v464/n7288/full/nature08820.html
Control of female gamete formation by a small RNA pathway in
Arabidopsis
pp628-632
Female gametes in flowering plants develop from a meiotic division of a
precursor
cell followed by mitotic divisions of one of the resulting haploid cells to
yield
the gametophyte. Here, ARGONAUTE 9 (AGO9) - a protein involved in RNA
interference
- is identified as a factor required for specification of the gametophyte.
AGO9
is found not in the cell destined to be the gametophyte, but in the
neighbouring
companion cells, suggesting that it functions in a non-cell-autonomous
manner.
Vianey Olmedo-Monfil et al.
doi:10.1038/nature08828
Abstract:
http://www.nature.com/nature/journal/v464/n7288/abs/nature08828.html
Article:
http://www.nature.com/nature/journal/v464/n7288/full/nature08828.html
----------------------
FUTURES
----------------------
The drained world p640
Deep thoughts.
Ian Watson
doi:10.1038/464640a
http://www.nature.com/nature/journal/v464/n7288/full/464640a.html
----------------------
Advance Online Publication
----------------------
24 March 2010
Genome-wide association study of 107 phenotypes in Arabidopsis thaliana
inbred lines
Susanna Atwell et al.
doi:10.1038/nature08800
Abstract:
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature08800.html
Article:
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature08800.html
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