Selective inhibition of BET bromodomains pp1067 - 1073
A new approach is used to target BET family bromodomains which are  found in transcriptional regulators where they mediate the recognition  of acetyl-lysine chromatin marks. Structural data reveal how the  compound JQ1 binds to the bromodomain of BRD4. BRD4 has been  implicated in a subtype of human squamous carcinomas, and JQ1 is found  to inhibit the growth of BRD4 dependent tumours in mouse models.
Panagis Filippakopoulos et al.
doi:10.1038/nature09504
Abstract: http://www.nature.com/nature/journal/v468/n7327/abs/nature09504.html
Article: http://www.nature.com/nature/journal/v468/n7327/full/nature09504.html

Driving the cell cycle with a minimal CDK control network pp1074 - 1079
To investigate the core engine of the eukaryotic mitotic cycle, a  minimal control network has been generated in fission yeast that  efficiently sustains cellular reproduction. Orderly progression  through the major events of the cell cycle is driven by oscillation of  an engineered minimal CDK module lacking much of the canonical  regulation.
Damien Coudreuse and Paul Nurse
doi:10.1038/nature09543
Abstract: http://www.nature.com/nature/journal/v468/n7327/abs/nature09543.html
Article: http://www.nature.com/nature/journal/v468/n7327/full/nature09543.html

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LETTERS
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Images of a fourth planet orbiting HR 8799 pp1080 - 1083
High-contrast near-infrared imaging of the nearby star HR 8799 has  shown three giant planets. Here, the presence of a fourth planet,  interior to and about the same mass as the other three, is reported.  The system, with this additional planet, represents a challenge for  current planet formation models as none of them can explain the in  situ formation of all four planets.
Christian Marois et al.
doi:10.1038/nature09684
Abstract: http://www.nature.com/nature/journal/v468/n7327/abs/nature09684.html
Article: http://www.nature.com/nature/journal/v468/n7327/full/nature09684.html

Spin–orbit qubit in a semiconductor nanowire pp1084 - 1087
Motion of electrons can influence their spins through a fundamental  effect called the spin–orbit interaction. Here, a spin–orbit  quantum bit (qubit) is implemented in an indium arsenide nanowire,  which should offer significant advantages for quantum computing. The  spin–orbit qubit is electrically controllable, and information can be  stored in the spin. Moreover, nanowires can serve as one dimensional  templates for scalable qubit registers, and are suited for both  electronic and optical devices.
S. Nadj-Perge, S. M. Frolov, E. P. A. M. Bakkers and L. P. Kouwenhoven
doi:10.1038/nature09682
Abstract: http://www.nature.com/nature/journal/v468/n7327/abs/nature09682.html
Article: http://www.nature.com/nature/journal/v468/n7327/full/nature09682.html

Atom-by-atom spectroscopy at graphene edge pp1088 - 1090
Electron microscopy has advanced to the stage where individual  elements can be identified with atomic resolution. Here it is shown to  be possible to get fine-structure spectroscopic information of  individual light atoms such as those of carbon, and so also probe  their chemical state. This capability is illustrated by investigating  the edges of a graphene sample, where it is possible to discriminate  between single-, double- and triple-coordinated carbon atoms.
Kazu Suenaga and Masanori Koshino
doi:10.1038/nature09664
Abstract: http://www.nature.com/nature/journal/v468/n7327/abs/nature09664.html
Article: http://www.nature.com/nature/journal/v468/n7327/full/nature09664.html

Mantle superplasticity and its self-made demise pp1091 - 1094
The unusual capability of solid crystalline materials to deform  plastically (known as superplasticity) has been found in metals and  even ceramics; however, no experimental studies have yet to  demonstrate this behaviour in geological materials. It is now  demonstrated that some synthetic rocks, which are good analogues for  Earth's mantle, undergo homogeneous elongation up to 500% under  subsolidus conditions. Calculations show that such superplastic flow  in the mantle is inevitably accompanied by significant grain growth  that can change fine-grained rocks to coarse-grained aggregates,  resulting in increasing mantle viscosity and finally termination of  superplastic flow.

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