《Nature》目录要览：2010-12-02出版
时间：2010-12-02 阅读： 我要评论:
Daisuke Nakada, Thomas L. Saunders and Sean J. Morrison
doi:10.1038/nature09571
Abstract: http://www.nature.com/nature/journal/v468/n7324/abs/nature09571.html
Article: http://www.nature.com/nature/journal/v468/n7324/full/nature09571.html
The Lkb1 metabolic sensor maintains haematopoietic stem cell survival pp659 - 663
Haematopoietic stem cells (HSCs) are very sensitive to energetic and oxidative stress, and modulation of the balance between their quiescence and proliferation is needed to respond to metabolic stress while preserving HSCs' long term regenerative capacity. Here the tumour suppressor Lkb1 is shown to have a crucial role in maintaining energy homeostasis in haematopoietic cells — an effect largely independent of AMPK and mTOR signalling.
Sushma Gurumurthy et al.
doi:10.1038/nature09572
Abstract: http://www.nature.com/nature/journal/v468/n7324/abs/nature09572.html
Article: http://www.nature.com/nature/journal/v468/n7324/full/nature09572.html
U1 snRNP protects pre-mRNAs from premature cleavage and polyadenylation pp664 - 668
Splicing is carried out by a collection of protein–RNA complexes known as snRNPs. The spliceosome contains equal quantities of the U1, U2, U4, U5 and U6 snRNPs, but the U1 snRNP is made in levels excess to the amounts needed to form spliceosomes, leading to the idea that excess U1s might have splicing independent functions. Here it is shown that the U1 snRNA interacts with some pre mRNAs whose introns have cryptic polyadenylation sites. This interaction prevents premature termination and polyadenylation of the pre mRNA.
Daisuke Kaida et al.
doi:10.1038/nature09479
Abstract: http://www.nature.com/nature/journal/v468/n7324/abs/nature09479.html
Article: http://www.nature.com/nature/journal/v468/n7324/full/nature09479.html
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A ground-based transmission spectrum of the super-Earth exoplanet GJ 1214b pp669 - 672
Three distinct models for the recently discovered super-Earth (masses 2–10 times that of Earth) planet GJ 1214b that are consistent with its mass and radius have been suggested. Breaking the degeneracy between these models requires obtaining constraints on the planet's atmospheric composition. Here, a ground based measurement of the transmission spectrum of GJ 1214b between 780 and 1,000 nm is reported. The lack of features in this spectrum rules out cloud free atmospheres composed primarily of hydrogen. If the planet's atmosphere is hydrogen-dominated, then it must contain clouds or hazes that are optically thick at pressures
Jacob L. Bean, Eliza Miller-Ricci Kempton and Derek Homeier
doi:10.1038/nature09596
Abstract: http://www.nature.com/nature/journal/v468/n7324/abs/nature09596.html
Article: http://www.nature.com/nature/journal/v468/n7324/full/nature09596.html
Trapped antihydrogen pp673 - 676
Antihydrogen, the bound state of an antiproton and a positron, has been produced at low energies at CERN since 2002. It is of fundamental interest for testing the standard model of elementary particles and interactions. However, experiments so far have produced antihydrogen that is not confined, precluding detailed study of its structure. Here, trapping of antihydrogen atoms is demonstrated, opening the door to precision measurements on anti atoms.
G. B. Andresen et al.
doi:10.1038/nature09610
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