《Nature》目录：2010-06-17出版
时间：2010-06-18 阅读： 我要评论:
Anja L. Dorrn et al.
doi:10.1038/nature09119
Abstract:
http://www.nature.com/nature/journal/v465/n7300/abs/nature09119.html
Article:
http://www.nature.com/nature/journal/v465/n7300/full/nature09119.html
TLR recognition of self nucleic acids hampers glucocorticoid activity in
lupus pp937-941
Glucocorticoids are widely used to treat patients with autoimmune diseases
such as systemic lupus erythematosus (SLE), but many treatment regimens
cannot maintain disease control in SLE patients. Here it is shown that the
stimulation of plasmacytoid dendritic cells through toll-like receptors TLR7
and TLR9 can account for the reduced activity of glucocorticoids to inhibit
the type I interferon pathway in SLE patients. Thus inhibitors of TLR7 and
TLR9 signalling might prove to be effective corticosteroid-sparing drugs.
Cristiana Guiducci et al.
doi:10.1038/nature09102
Abstract:
http://www.nature.com/nature/journal/v465/n7300/abs/nature09102.html
Article:
http://www.nature.com/nature/journal/v465/n7300/full/nature09102.html
Termination of autophagy and reformation of lysosomes regulated by
mTOR pp942-946
When cells are starved, the enzyme TOR is inhibited, inducing autophagy. In
this process, autophagosomes sequester intracellular components and then
fuse with lysosomes, producing autolysosomes in which cargo is degraded to
regenerate nutrients. Now, a mechanism is revealed by which lysosomes are
re-formed. When starvation conditions are prolonged, mTOR is re-activated;
this attenuates autophagy and results in tubules and vesicles extruding from
the autolysosome and maturing into functional lysosomes.
Li Yu et al.
doi:10.1038/nature09076
Abstract:
http://www.nature.com/nature/journal/v465/n7300/abs/nature09076.html
Article:
http://www.nature.com/nature/journal/v465/n7300/full/nature09076.html
Principles of stop-codon reading on the ribosome pp947-950
Stop codons in messenger RNA define when a protein sequence has been
completely synthesized; such codons bind release factors (RFs), which cause
the newly made protein to be released. Structures of RFs alone and in
combination with the ribosome have been reported, but the energetics of the
reaction in the presence of codons had not been determined. Here, molecular
dynamics simulations of 14 termination complexes are used to define how
termination is achieved and how the RFs distinguish different sequences.
Johan Sund, Martin Ander and Johan Aqvist
doi:10.1038/nature09082
Abstract:
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| 《Nature》目录要览：2010-12-23出版 |
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| 《Nature》目录要览：2010-12-09出版 |
| 《Nature》目录要览：2010-12-02出版 |
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来源：Nature 作者：Environmentor （环境人 Environmentor.Cn）
