Identification of two evolutionarily conserved genes regulating processing
of
engulfed apoptotic cells    pp778-782
In multicellular organisms, apoptotic cells are removed from tissues by
phagocytes, which recognize and engulf the dying cells. The molecular
mechanisms underlying the subsequent degradation of the cells have been
unclear. Here, two evolutionarily conserved genes have been identified that
are required for such processing in Caenorhabditis elegans and mammals. An
understanding of these events could lead to new treatments for diseases
associated with poor engulfment and destruction of dying cells.
Jason M. Kinchen and Kodi S. Ravichandran
doi:10.1038/nature08853
Abstract:
http://www.nature.com/nature/journal/v464/n7289/abs/nature08853.html
Article:
http://www.nature.com/nature/journal/v464/n7289/full/nature08853.html

Spatial control of EGF receptor activation by reversible dimerization on
living cells    pp783-787
Signalling through the epidermal growth factor receptor (EGFR) is preceded
by its dimerization, which has typically been thought to occur through a
ligand-induced conformational change. Here, the dimerization dynamics of
individual EGFR molecules have been determined in living cells in real time,

using a quantum-dot-based approach. Unliganded EGFR molecules undergo
spontaneous and reversible dimerization; these pre-formed dimers are
primed for ligand binding and signalling and are enriched at the cell
periphery.
Inhee Chung et al.
doi:10.1038/nature08827
Abstract:
http://www.nature.com/nature/journal/v464/n7289/abs/nature08827.html
Article:
http://www.nature.com/nature/journal/v464/n7289/full/nature08827.html

NINJA connects the co-repressor TOPLESS to jasmonate signalling    pp788-791
In plants, the hormone jasmonoyl-isoleucine (JA-Ile) regulates growth,
development and defence against pathogens. Proteins of the JAZ family
repress JA-Ile-dependent gene expression, but the mechanism has been
unclear. Here, an adaptor protein, NINJA, has been identified, which r
ecruits co-repressor proteins that are known to mediate auxin-responsive
gene expression as well. Hence these co-repressors are part of general
repression complexes that are recruited to several different signalling
pathways.
Laurens Pauwels et al.
doi:10.1038/nature08854
Abstract:
http://www.nature.com/nature/journal/v464/n7289/abs/nature08854.html
Article:
http://www.nature.com/nature/journal/v464/n7289/full/nature08854.html

Phosphorylation of histone H3T6 by PKC[bgr]I controls demethylation at
histone H3K4    pp792-796
The amino-terminal tails of histone proteins are subject to a variety of
post-translational modifications; addition or removal of these 'marks'
facilitates gene activation or silencing. Here, a mechanism is defined that
modulates the activity of the dual-specificity histone demethylase LSD1

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